CONTENT EXTRACTION BASED ON VIDEO CO-SEGMENTATION

Ph.DDOCTOR OF PHILOSOPH

Predicting Alzheimer's Disease by Hierarchical Graph Convolution from Positron Emission Tomography Imaging

Imaging-based early diagnosis of Alzheimer Disease (AD) has become an effective approach, especially by using nuclear medicine imaging techniques such as Positron Emission Topography (PET). In various literature it has been found that PET images can be better modeled as signals (e.g. uptake of florbetapir) defined on a network (non-Euclidean) structure which is governed by its underlying graph patterns of pathological progression and metabolic connectivity. In order to effectively apply deep learning framework for PET image analysis to overcome its limitation on Euclidean grid, we develop a solution for 3D PET image representation and analysis under a generalized, graph-based CNN architecture (PETNet), which analyzes PET signals defined on a group-wise inferred graph structure. Computations in PETNet are defined in non-Euclidean, graph (network) domain, as it performs feature extraction by convolution operations on spectral-filtered signals on the graph and pooling operations based on hierarchical graph clustering. Effectiveness of the PETNet is evaluated on the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset, which shows improved performance over both deep learning and other machine learning-based methods.Comment: Jiaming Guo, Wei Qiu and Xiang Li contribute equally to this wor

A Comprehensive Comparison of Projections in Omnidirectional Super-Resolution

Super-Resolution (SR) has gained increasing research attention over the past few years. With the development of Deep Neural Networks (DNNs), many super-resolution methods based on DNNs have been proposed. Although most of these methods are aimed at ordinary frames, there are few works on super-resolution of omnidirectional frames. In these works, omnidirectional frames are projected from the 3D sphere to a 2D plane by Equi-Rectangular Projection (ERP). Although ERP has been widely used for projection, it has severe projection distortion near poles. Current DNN-based SR methods use 2D convolution modules, which is more suitable for the regular grid. In this paper, we find that different projection methods have great impact on the performance of DNNs. To study this problem, a comprehensive comparison of projections in omnidirectional super-resolution is conducted. We compare the SR results of different projection methods. Experimental results show that Equi-Angular cube map projection (EAC), which has minimal distortion, achieves the best result in terms of WS-PSNR compared with other projections. Code and data will be released.Comment: Accepted to ICASSP202

CABM: Content-Aware Bit Mapping for Single Image Super-Resolution Network with Large Input

With the development of high-definition display devices, the practical scenario of Super-Resolution (SR) usually needs to super-resolve large input like 2K to higher resolution (4K/8K). To reduce the computational and memory cost, current methods first split the large input into local patches and then merge the SR patches into the output. These methods adaptively allocate a subnet for each patch. Quantization is a very important technique for network acceleration and has been used to design the subnets. Current methods train an MLP bit selector to determine the propoer bit for each layer. However, they uniformly sample subnets for training, making simple subnets overfitted and complicated subnets underfitted. Therefore, the trained bit selector fails to determine the optimal bit. Apart from this, the introduced bit selector brings additional cost to each layer of the SR network. In this paper, we propose a novel method named Content-Aware Bit Mapping (CABM), which can remove the bit selector without any performance loss. CABM also learns a bit selector for each layer during training. After training, we analyze the relation between the edge information of an input patch and the bit of each layer. We observe that the edge information can be an effective metric for the selected bit. Therefore, we design a strategy to build an Edge-to-Bit lookup table that maps the edge score of a patch to the bit of each layer during inference. The bit configuration of SR network can be determined by the lookup tables of all layers. Our strategy can find better bit configuration, resulting in more efficient mixed precision networks. We conduct detailed experiments to demonstrate the generalization ability of our method. The code will be released.Comment: Accepted to CVPR202

Comparative Component Analysis of Exons with Different Splicing Frequencies

Transcriptional isoforms are not just random combinations of exons. What has caused exons to be differentially spliced and whether exons with different splicing frequencies are subjected to divergent regulation by potential elements or splicing signals? Beyond the conventional classification for alternatively spliced exons (ASEs) and constitutively spliced exons (CSEs), we have classified exons from alternatively spliced human genes and their mouse orthologs (12,314 and 5,464, respectively) into four types based on their splicing frequencies. Analysis has indicated that different groups of exons presented divergent compositional and regulatory properties. Interestingly, with the decrease of splicing frequency, exons tend to have greater lengths, higher GC content, and contain more splicing elements and repetitive elements, which seem to imply that the splicing frequency is influenced by such factors. Comparison of non-alternatively spliced (NAS) mouse genes with alternatively spliced human orthologs also suggested that exons with lower splicing frequencies may be newly evolved ones which gained functions with splicing frequencies altered through the evolution. Our findings have revealed for the first time that certain factors may have critical influence on the splicing frequency, suggesting that exons with lower splicing frequencies may originate from old repetitive sequences, with splicing sites altered by mutation, gaining novel functions and become more frequently spliced